GeNIe can be used on a Mac with Boot Camp (available only on Intel-based Macs, boots the computer into Windows installed on a separate partition), a virtual machine (VM) such as VirtualBox or Parallels, or with Wine (a compatibility layer capable of running Windows applications). Boot Camp and VM-based solutions give the user access to a complete Windows operating system, where GeNIe can be installed and run natively. Wine is an open source project. It can be downloaded and used for free, and works on Apple Silicon (ARM-based) Macs.

Note that recent versions of macOS, starting with 10.15 Catalina, released in 2019, do not support 32-bit applications. If you need to use Wine to run 32-bit GeNIe (such as GeNIe Academic) follow the instructions for 32-bit mode below.

Another Wine-based option for both 32-bit and 64-bit GeNIe is Crossover by CodeWeavers. Crossover makes it easier to use Wine and CodeWeavers provides excellent technical support to its users. All purchases of Crossover are used to directly fund the developers working on Wine. Crossover is available at https://www.codeweavers.com/.

Running 64-bit GeNIe on macOS with Wine:

1.Install Wine on your Mac. Follow the instructions at https://wiki.winehq.org/MacOS.

2.Download 64-bit MSI GeNIe installer. Note that the EXE installer for 64-bit GeNIe will not work, because the installer stub is 32-bit.

3.Run Wine from Launchpad. This opens the Terminal window configured to run Windows programs. In Wine's terminal, use the following command to run the MSI installer. The example below assumes that the installer is located in user's Desktop folder, and its filename is genie-setup-4.1.3315-x64.msi.

wine64 msiexec /i ~/Desktop/genie-setup-4.1.3315-x64.msi

4.In Wine's terminal, use the cd command to navigate to GeNIe's installation directory. Assuming that GeNIe was installed in its default location, the command is:

cd ".wine/drive_c/Program Files/GeNIe 4.1"

Note that quotes are required, because some of the directories' names contain spaces.

5.After changing the directory, run GeNIe:

wine64 genie.exe

This starts GeNIe using appropriate Wine configuration.

Running 32-bit GeNIe Academic on macOS with Wine

1.Install the wine-crossover package on your Mac using homebrew. The package contains code developed for the commercial Crossover product, but is free to download and use.

brew install --cask --no-quarantine gcenx/wine/wine-crossover

2.Download 32-bit GeNIe installer, either EXE or MSI.

3.Run "Wine Crossover" from Launchpad. This opens the Terminal window configured to run Windows programs. In Wine Crossover's terminal, use the following command to run the MSI installer. The example below assumes that the installer is located in user's Desktop folder, and its filename is genie-academic-setup-4.1.3315-x64.msi.

wine msiexec /i ~/Desktop/genie-academic-setup-4.1.3315-x64.msi